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Modified Citrus Pectin & Heavy Metal Removal
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From Dr. Isaac Eliaz:

On August 25th, Dorena Rode and I presented our pilot clinical trial on the effect of MCP on urinary excretion of heavy metals.

The results or the pilot clinical trial are shown below.

The clinical trial results are also supported by a case report of the first patient whose body burden of toxic heavy metals was evaluated at baseline and after ten months on MCP at 15 grams per day.

A repeat DMPS challenge showed a decrease of 68% in the body load of mercury and an almost 50% decrease in lead and arsenic.

Based on my clinical experience and the proposed mechanism of action, I think that MCP is exerting its chelating effects in the bloodstream.

This means that MCP can and should be used on an ongoing basis as a gentle chelator.

As the heavy metal concentration (as well as levels of some environmental toxins/carcinogenic compounds like 1,2-dimethylhydrazine) is reduced in the bloodstream, the gradient (concentration difference between the tissue and the blood) allows the toxic heavy metals to shift from the tissue to the bloodstream where they then can be removed by MCP.

My current recommendations for the usage of MCP for chelation is as follows:

1. For individuals with high burden of heavy metals- 15 grams per day (5 grams x3 /day) for 9-12 months. 2. For individuals with a lower heavy metal burden, or with limited budget: 15 grams per day, first week of the month. 5 grams per day during the remaining time- for one year.

Since MCP exerts its benefits in the bloodstream, it can be used for heavy metal chelation even if you still have amalgam fillings. And remember- not every MCP is the right MCP, so make sure that you are using the right product that has been researched and validated!!

The effect of modified citrus pectin on the urinary excretion of toxic elements.

Authors: Isaac Eliaz, Dorena Rode

Source: Fifth Annual Conference of Environmental Health Scientists: Nutritional Toxicology and Metabolomics, August 2003, University of California, Davis


Background and Objective

Pectin is a soluble fiber effective at binding toxic and radioactive metals and has been applied to environmental clean-up and detoxification in humans. Due to its large molecular size, it is not readily absorbed and its actions are limited to the gut.

Modified citrus pectin is a smaller molecular weight compound that can be absorbed into the bloodstream.

This study was undertaken to evaluate the effect of modified citrus pectin on the urinary excretion of toxic elements in healthy individuals.


Seven subjects were recruited from a convenience sample. The subjects ingested 15 grams of PectaSol® Modified Citrus Pectin (MCP) each day for five days and 20 grams on day six.

Prior to commencing with the MCP the subjects collected a 24 hour urine sample as baseline. 24 hour urine samples were collected on day one and day six for comparison.

The samples were analyzed by ICP-MS (inductively coupled plasma -mass spectrophotometer) for arsenic, lead, mercury, cadmium, aluminum, antimony, beryllium, bismuth, nickle, platinum, thallium, thorium, tin, tungsten, and uranium.


In the first 24 hours of MCP administration the urinary excretion of arsenic and tungsten increased significantly (130% and 210% of baseline levels, respectively; p<0.05).

In this same period, the excretion of mercury and cadmium approached significance (150% and 230% of baseline respectively; p<0.1). On day six, urinary excretion was significantly increased for cadmium and tungsten (150% and 270% of baseline, respectively; p<0.05).

In addition, lead showed a dramatic increase in excretion (560% over baseline) with p<0.08.


Oral administration of modified citrus pectin (molecular weight < 20 kDaltons, degree of esterification <10%) resulted in significant increases in the urinary excretion of arsenic, cadmium, and tungsten.

Mercury and lead also demonstrated increased excretion approaching significance. Further investigations into the mechanism by which the urinary excretion of toxic elements was increased is justified; although it is likely the effect is due to the known chelation properties of pectin.

This preliminary work suggests that the nutritional supplement, MCP, may assist in the elimination of toxic elements from the body.

These results should be verified with a larger scale trial and additional studies involving individuals with toxic element burden is also warranted.

Ann's NOTE: This study was done in only 7 people. That is very small. As the conclusion states, a larger trial is needed (before physicians will be able to rely on the results).


Dr. Isaac Eliaz Newsletter

LINK to newsletter on Modified Citrus Pectin, etc.